Jeffrey D Lebensburger, Rakeshkumar J Patel, Prasannalaxmi Palabindela, Christina J Bemrich-Stolz, Thomas H Howard, Lee M HilliardDivision of Pediatric Hematology Oncology, University of Alabama at Birmingham, Birmingham, AL, USAPurpose: Patients with hemoglobin SC (Hb SC) and hemoglobin SB+ (Hb SB+) thalassemia suffer from frequent hospitalization
Understanding the mechanisms of evasive resistance in cancer is of great importance to develop efficient therapies.Analyzing the molecular mechanisms underlying therapy resistance of hepatocellular carcinoma (HCC), we have discovered a kinase-activity independent role of LATS1 (large tumor suppressor) but not LATS2 in regulating sorafenib-induced l
Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited renal disease with an incidence of 1 in 400 to 1000.The disease is genetically heterogeneous, with two genes identified: PKD1 (16p13.3) and PKD2 (4q21).Molecular diagnosis of the disease in at-risk individuals is complicated due to the structural c
Our objective was to evaluate an open-label, multicenter, single-arm CITRONELLA study to appraise whether amrubicin therapy improves patients with refractory small-cell lung cancer in Chinese clinical study.Patients (n=95) with refractory small-cell lung cancer received 3 consecutive days amrubicin therapy for 21 days.Overall response rate of respo